Experimental syphilis: guinea pig model.
نویسندگان
چکیده
منابع مشابه
Experimental syphilis: guinea pig model.
Outbred Hartley male guinea pigs (300-400 g) were infected intradermally with various concentrations of Treponema pallidum Nichols strain in the pubic region. The median lethal dose (ID50) was approximately 10(5). The animals produced lesions visible by darkfield microscopy, treponemal antibodies (IgG only), and histopathological changes in the lymphoid organs. Though less susceptible to T pall...
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Neonates born to female guinea pigs of either a highly susceptible (C4D) or a resistant (Albany) strain, infected prior to or during pregnancy with a single dose of Treponema pallidum, showed in their sera from the first day of life immunoglobulin M (IgM) antibodies to T. pallidum, circulating immune complexes consisting of IgM antibodies and treponemal antigens, and IgM rheumatoid factor. Alth...
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Treponema pallidum-immobilizing (TPI) antibodies were examined in intradermally infected inbred strain 13 and adoptively immune inbred strain 2 guinea pigs. Both strains of animals produced TPI antibodies at or after 90 days of infection. TPI antibodies were not associated with the protective mechanism(s) operative after challenge in adoptively immune animals.
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Chromosomal patterns of experimental animals are useful tools for cytogenetics research and animal breeding. Chromosome investigations of the hairless guinea pig are rare, therefore, karyotype of hairless guinea pigs (twelve male and female) was studied using metaphase spreads of bone marrows and G banding techniques. The chromosomes diploid number was 2n= 64 and polymorphism of three type chro...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 1983
ISSN: 1368-4973
DOI: 10.1136/sti.59.3.157